Microbiota supplementation with Bifidobacterium and Lactobacillus modifies the preterm infant gut microbiota and metabolome
作者： Cristina Alcon-Giner , Matthew J. Dalby , Shabhonam Caim , Jennifer Ketskemety , Alex Shaw
DOI: 10.1101/698092
关键词:
摘要: Abstract Supplementation with members of the early-life microbiota or ‘probiotics’ is becoming increasingly popular to attempt beneficially manipulate preterm gut microbiota. We performed a large longitudinal study comprising two groups; 101 orally supplemented Bifidobacterium and Lactobacillus (Bif/Lacto) 133 non-supplemented (Control) matched by age, sex, birth-mode, diet. 16S rRNA metataxonomic profiling on stool samples (n = 592) indicated predominance Bifidobacterium, reduction pathobionts in Bif/Lacto group. Metabolic phenotyping found parallel increase fecal acetate lactate group compared Control group, which positively correlated abundance consistent ability strain metabolize human milk oligosaccharides reduced pH. This demonstrates that supplementation can modify microbiome gastrointestinal environment more closely resemble full-term infant.
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