Bifidobacterial Dominance of the Gut in Early Life and Acquisition of Antimicrobial Resistance.

摘要: Bifidobacterium species are important commensals capable of dominating the infant gut microbiome, in part by producing acids that suppress growth other taxa. less prone to possessing antimicrobial resistance (AMR) genes (ARGs) than taxa may colonize infants. Given AMR is a growing public health crisis and ARGs present microbiome humans from early life, this study examines correlation between Bifidobacterium-dominated levels, measured culture-independent metagenomic approach both life as infants become toddlers. In general, dominance associated with significant reduction Bangladeshi cohort, number acquired abundance genes. However, year 2, had no differences related their early-life levels. A generalized linear model including all previously published Swedish cohort found negative association log-transformed total thus confirming relationship levels AMR. cohorts, there was change later-life high-Bifidobacterium but low-Bifidobacterium These results support hypothesis help reduce colonization containing ARGs.IMPORTANCE Infants vulnerable an array infectious diseases, serve reservoir for pathogens, reducing health. This demonstrates high reduced suggests probiotic interventions increase have potential effect not sustained at 2 age infants, underscoring need more detailed studies biogeography timing acquisition.