Circular RNA hsa_circ_0102231 sponges miR-145 to promote non-small cell lung cancer cell proliferation by up-regulating the expression of RBBP4.

摘要: Circular RNAs (circRNAs) are important regulators in various cancers. Previous studies have found that hsa_circ_0102231 is an oncogene lung adenocarcinoma. Here, we investigated its mechanism the development of non-small cell cancer (NSCLC). We detected levels five NSCLC lines and one normal bronchial epithelium line. The interaction between miR-145 was predicted confirmed by pull-down luciferase assays. nuclear mass separation assay fluorescence situ hybridization were used to detect distribution hsa_circ_0102231. Cell Counting Kit-8 Transwell assays assess proliferative invasive ability. Western blot RT-qPCR, respectively, protein mRNA RBBP4. RBBP4 promoter activity with a assay. level higher cells. mainly localized cytoplasm. promotes proliferation invasion sponge for miR-145. significantly decreases activity, levels. promote Our findings suggest mediating miR-145/RBBP4 axis NSCLC, indicating it might be potential target treatment.