MiR-145 acts as a metastasis suppressor by targeting metadherin in lung cancer
作者： Mingzhi Wang , Jianhua Wang , Jianming Deng , Xuejun Li , Weiguang Long
DOI: 10.1007/S12032-014-0344-6
关键词:
摘要: MiR-145 has been reported to be downregulated in multiple tumors. It acts as a tumor suppressor lung cancer. In this study, we investigated the potential effects of miR-145 on invasion and metastasis molecular mechanism non-small cell was NSCLC specimens significantly correlated with advanced clinical stage lymph node metastasis. addition, AEG-1/MTDH direct target miR-145, expression inversely tissues. Ectopic suppressed cells. overexpression partially reversed suppressive effect miR-145. These findings provide novel insights therapeutic applications for treatment NSCLC.
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