AEG-1/MTDH/LYRIC: clinical significance.
作者： Devanand Sarkar , Paul B Fisher , None
DOI: 10.1016/B978-0-12-401676-7.00002-4
关键词: Angiogenesis 、 Disease 、 Biology 、 Biomarker (medicine) 、 Cancer cell 、 MTDH 、 Cancer 、 Metastasis 、 Cancer research 、 Clinical significance
摘要: "Gain-of-function" and "loss-of-function" studies in human cancer cells analysis of a transgenic mouse model have convincingly established that AEG-1/MTDH/LYRIC performs seminal role regulating proliferation, invasion, angiogenesis, metastasis, chemoresistance, the salient defining hallmarks cancer. These observations are strongly buttressed by clinicopathologic correlations expression diverse array cancers distinguishing as an independent biomarker for highly aggressive metastatic disease with poor prognosis. has been shown to be marker predicting response chemotherapy, serum anti-AEG-1/MTDH/LYRIC antibody titer also serves predictor advanced stages However, inconsistent findings reported regarding localization protein nucleus or cytoplasm utility nuclear cytoplasmic predict course prognosis disease. This chapter provides comprehensive existing literature emphasize common conflicting relative clinical significance
sci-hub.se 参考文章(269)
Annie On-On Chan, Benjamin Chun-Yu Wong, Shiu-Kum Lam, Gastric cancer: past, present and future. Canadian Journal of Gastroenterology & Hepatology. ,vol. 15, pp. 469- 474 ,(2001) , 10.1155/2001/850308
Xiao Lv, Xue-Ling Ge, Li-Li Feng, Kang Lu, Pei-Pei Li, Na Chen, Xiao-Hui Meng, Xin Wang, Metadherin interference inhibits proliferation and enhances chemo-sensitivity to doxorubicin in diffuse large B cell lymphoma. International Journal of Clinical and Experimental Medicine. ,vol. 7, pp. 2081- 2086 ,(2014)
Evan K. Noch, Kamel Khalili, The Role of AEG-1/MTDH/LYRIC in the Pathogenesis of Central Nervous System Disease Advances in Cancer Research. ,vol. 120, pp. 159- 192 ,(2013) , 10.1016/B978-0-12-401676-7.00006-1
Adam Doble, The role of excitotoxicity in neurodegenerative disease: implications for therapy. Pharmacology & Therapeutics. ,vol. 81, pp. 163- 221 ,(1999) , 10.1016/S0163-7258(98)00042-4
Thomas D Gilmore, The Re1/NF-kappa B/I kappa B signal transduction pathway and cancer. Cancer treatment and research. ,vol. 115, pp. 241- 265 ,(2003)
Devanand Sarkar, AEG-1/MTDH/LYRIC in Liver Cancer Advances in Cancer Research. ,vol. 120, pp. 193- 221 ,(2013) , 10.1016/B978-0-12-401676-7.00007-3
Xiao Lv, Xue-Ling Ge, Li-Li Feng, Kang Lu, Pei-Pei Li, Na Chen, Hui Zhou, Xin Wang, Qing-Min Yao, Metadherin contribute to BCR signaling in chronic lymphocytic leukemia. International Journal of Clinical and Experimental Pathology. ,vol. 7, pp. 1588- 1594 ,(2014)
Hai Yan Liu, Chun Xi Liu, Bo Han, Xin Ying Zhang, Ruo Peng Sun, AEG-1 is associated with clinical outcome in neuroblastoma patients. Cancer Biomarkers. ,vol. 11, pp. 115- 121 ,(2012) , 10.3233/CBM-2012-0268
Zhangxiu He, Meihui He, Chao Wang, Baozhan Xu, Liping Tong, Junming He, Bowen Sun, Lanlan Wei, Ming Chu, None, Prognostic significance of astrocyte elevated gene-1 in human astrocytomas. International Journal of Clinical and Experimental Pathology. ,vol. 7, pp. 5038- 5044 ,(2014)
Luni Emdad, Swadesh K. Das, Santanu Dasgupta, Bin Hu, Devanand Sarkar, Paul B. Fisher, AEG-1/MTDH/LYRIC: Signaling Pathways, Downstream Genes, Interacting Proteins, and Regulation of Tumor Angiogenesis Advances in Cancer Research. ,vol. 120, pp. 75- 111 ,(2013) , 10.1016/B978-0-12-401676-7.00003-6