摘要: Hepatocellular carcinoma (HCC) is a highly virulent malignancy with diverse etiology. Identification of common mediator aggressive progression HCC would be extremely beneficial not only for diagnostic/prognostic purposes but also developing targeted therapies. AEG-1/MTDH/LYRIC gene amplified in human patients, and overexpression has been identified high percentage both hepatitis B virus C positive cases, suggesting its key role regulating hepatocarcinogenesis. Important insights into the molecular mechanisms mediating oncogenic properties AEG-1/MTDH/LYRIC, especially chemoresistance, angiogenesis, metastasis, have obtained from studies using model. Additionally, analysis model facilitated identification downstream genes interacting proteins, thereby unraveling novel players development leading to interventional strategies. Characterization hepatocyte-specific transgenic mouse (Alb/AEG-1) revealed aspects function vivo contexts. Combination inhibition chemotherapy documented significant efficacy abrogating xenografts nude mice indicating need effective strategies obtain objective response survival benefits terminal patients.
sci-hub.se 参考文章(83)
Scott E Schaus, Rachel Gredler, Devaraja Rajasekaran, Ayesha Siddiq, Devanand Sarkar, Ulla Hansen, Paul B Fisher, Prasanna K Santhekadur, Dong Chen, The transcription factor LSF: a novel oncogene for hepatocellular carcinoma. American Journal of Cancer Research. ,vol. 2, pp. 269- 285 ,(2012)
L. X. Duan, M. A. Feitelson, Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma. American Journal of Pathology. ,vol. 150, pp. 1141- 1157 ,(1997)
B. K. Yoo, L. Emdad, R. Gredler, C. Fuller, C. I. Dumur, K. H. Jones, C. Jackson-Cook, Z.-z. Su, D. Chen, U. H. Saxena, U. Hansen, P. B. Fisher, D. Sarkar, Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 8357- 8362 ,(2010) , 10.1073/PNAS.1000374107
Yasuyo Ishizaki, Satoshi Ikeda, Masahiko Fujimori, Yosuke Shimizu, Takeshi Kurihara, Toshiyuki Itamoto, Akira Kikuchi, Masazumi Okajima, Toshimasa Asahara, Immunohistochemical analysis and mutational analyses of β-catenin, Axin family and APC genes in hepatocellular carcinomas International Journal of Oncology. ,vol. 24, pp. 1077- 1083 ,(2004) , 10.3892/IJO.24.5.1077
Jie Yang, Tuuli Välineva, Jingxin Hong, Tianxu Bu, Zhi Yao, Ole N. Jensen, Mikko J. Frilander, Olli Silvennoinen, Transcriptional co-activator protein p100 interacts with snRNP proteins and facilitates the assembly of the spliceosome Nucleic Acids Research. ,vol. 35, pp. 4485- 4494 ,(2007) , 10.1093/NAR/GKM470
Josep M. Llovet, Jordi Bruix, Molecular targeted therapies in hepatocellular carcinoma. Hepatology. ,vol. 48, pp. 1312- 1327 ,(2008) , 10.1002/HEP.22506
Josep M Llovet, Sergio Ricci, Vincenzo Mazzaferro, Philip Hilgard, Edward Gane, Jean-Frédéric Blanc, Andre Cosme De Oliveira, Armando Santoro, Jean-Luc Raoul, Alejandro Forner, Myron Schwartz, Camillo Porta, Stefan Zeuzem, Luigi Bolondi, Tim F Greten, Peter R Galle, Jean-François Seitz, Ivan Borbath, Dieter Häussinger, Tom Giannaris, Minghua Shan, Marius Moscovici, Dimitris Voliotis, Jordi Bruix, None, Sorafenib in Advanced Hepatocellular Carcinoma The New England Journal of Medicine. ,vol. 359, pp. 378- 390 ,(2008) , 10.1056/NEJMOA0708857
Dong-chul Kang, Zao-zhong Su, Devanand Sarkar, Luni Emdad, David J. Volsky, Paul B. Fisher, Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1 Gene. ,vol. 353, pp. 8- 15 ,(2005) , 10.1016/J.GENE.2005.04.006
Josep M Llovet, Jordi Bruix, Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival Hepatology. ,vol. 37, pp. 429- 442 ,(2003) , 10.1053/JHEP.2003.50047
Daniel B. Longley, D. Paul Harkin, Patrick G. Johnston, 5-Fluorouracil: mechanisms of action and clinical strategies Nature Reviews Cancer. ,vol. 3, pp. 330- 338 ,(2003) , 10.1038/NRC1074