Metadherin contribute to BCR signaling in chronic lymphocytic leukemia.

摘要: We have reported Metadherin (MTDH) was proven to be overexpression and involved in malignance of chronic lymphocytic leukemia (CLL) via Wnt signaling pathway. In this study, we further investigate the role MTDH regulation BCR pathway CLL. Six CLL samples whose cells were proliferation after activation chosen from patients with unmutated IgVH. CCK-8 method used evaluate rate. expression measured by quantitative PCR Western blot. After activation, there exist upregulation mRNA protein level all six (P<0.05). cell line MEC-1, observed same pro-proliferation effect accompanying elevated expression. The effects MEC-1 can inhibited interference. results study indicate that And imply a potential therapy target