The Role of AEG-1/MTDH/LYRIC in the Pathogenesis of Central Nervous System Disease

摘要: Astrocyte-elevated gene-1 (AEG-1/MTDH/LYRIC) is a potent oncogene that regulates key cellular processes underlying disease of the central nervous system (CNS). From its involvement in human immunodeficiency virus (HIV)-1 infection to role neurodegenerative and malignant brain tumors, AEG-1/MTDH/LYRIC facilitates survival proliferation through control multitude molecular signaling cascades. induction by HIV-1 TNF highlights importance viral infection, incorporation into vesicles supports potential active replication. Overexpression brains Huntington’s patients suggests function disease, association with genetic polymorphisms large genome-wide studies migraine possible pathogenesis headaches. In field cancer, promotes angiogenesis, migration, invasion, enhanced tumor metabolism oncogenic response external stress cues mechanisms inhibit further growth, activates pathways bypass cell checkpoints potentiates signals enhance tumorigenesis. As an aberrant within CNS, represents important therapeutic target for treatment neurological disease.