Upregulation of AEG-1 Involves in Schwann Cell Proliferation and Migration After Sciatic Nerve Crush.
作者： Youhua Wang , Weidong Zhang , Xudong Zhu , Yi Wang , Xingxing Mao
DOI: 10.1007/S12031-016-0782-Z
关键词: Cell biology 、 PI3K/AKT/mTOR pathway 、 Protein kinase B 、 Schwann cell 、 Central nervous system 、 MTDH 、 Cell growth 、 Neuroscience 、 Schwann cell proliferation 、 Biology 、 Sciatic nerve
摘要: Astrocyte-elevated gene-1 (AEG-1), also known as metadherin (MTDH) and lysine-rich CEACAM1 coisolated (LYRIC), has emerged an important oncogene that regulates key cellular processes including apoptosis, migration, invasion, proliferation, differentiation. It was reported AEG-1 enhanced breast cancer cells migration in a NF-κB-dependent manner. Also, contributed cell proliferation through the PI3K-Akt/cyclin pathway. Besides, is implicated diverse physiological pathological diseases of central nervous system (CNS), such brain tumors, neuroblastomas, neurodegeneration, neuronal development. However, role process peripheral regeneration after injury remains virtually unknown. In this study, we investigated spatiotemporal expression rat sciatic nerve crush model. At its peak expression, expressed mainly Schwann distal segment from injury, but had few colocalizations axons. parallel with proliferating nuclear antigen (PCNA). vitro, detected increased during tumor necrosis factor α (TNF-α)-induced proliferation. Meanwhile, interference inhibited both cells. conclusion, speculated involved biochemical responses (SNC).
springer.com
sci-hub.se 参考文章(40)
LAWRENCE J. KOEP, BRUCE W. KONIGSMARK, EDWARD E. SPEHBER, Cellular changes in the human supraoptic and paraventricular hypothalamic nuclei in dehydration. Journal of Neuropathology and Experimental Neurology. ,vol. 29, pp. 254- 265 ,(1970) , 10.1097/00005072-197004000-00007
Byoung Kwon Yoo, Luni Emdad, Seok-Geun Lee, Zao-zhong Su, Prasanna Santhekadur, Dong Chen, Rachel Gredler, Paul B. Fisher, Devanand Sarkar, Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology Pharmacology & Therapeutics. ,vol. 130, pp. 1- 8 ,(2011) , 10.1016/J.PHARMTHERA.2011.01.008
S-G Lee, Z-Z Su, L Emdad, D Sarkar, T F Franke, P B Fisher, Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling Oncogene. ,vol. 27, pp. 1114- 1121 ,(2008) , 10.1038/SJ.ONC.1210713
DONALD L. SCHOTLAKD, An electron microscopic investigation of myotonic dystrophy. Journal of Neuropathology and Experimental Neurology. ,vol. 29, pp. 241- 253 ,(1970) , 10.1097/00005072-197004000-00006
Young-Jin Son, Wesley J Thompson, Schwann cell processes guide regeneration of peripheral axons Neuron. ,vol. 14, pp. 125- 132 ,(1995) , 10.1016/0896-6273(95)90246-5
Devanand Sarkar, Eun Sook Park, Luni Emdad, Seok-Geun Lee, Zao-zhong Su, Paul B. Fisher, Molecular Basis of Nuclear Factor-κB Activation by Astrocyte Elevated Gene-1 Cancer Research. ,vol. 68, pp. 1478- 1484 ,(2008) , 10.1158/0008-5472.CAN-07-6164
S -G Lee, H -Y Jeon, Z -Z Su, J E Richards, N Vozhilla, D Sarkar, T Van Maerken, P B Fisher, Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma. Oncogene. ,vol. 28, pp. 2476- 2484 ,(2009) , 10.1038/ONC.2009.93
Xiaoyan Li, Xiaoli Kong, Qiang Huo, Haiyang Guo, Shi Yan, Cunzhong Yuan, Meena S. Moran, Changshun Shao, Qifeng Yang, Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition Cancer Science. ,vol. 102, pp. 1151- 1157 ,(2011) , 10.1111/J.1349-7006.2011.01919.X
Xinhui Zhu, Li Yao, Aisong Guo, Aihong Li, Huiqing Sun, Ning Wang, Hanzhang Liu, Zhiqin Duan, Jianhua Cao, CAP1 was associated with actin and involved in Schwann cell differentiation and motility after sciatic nerve injury. Journal of Molecular Histology. ,vol. 45, pp. 337- 348 ,(2014) , 10.1007/S10735-013-9554-Z
Boudewijn M. Th. Burgering, Paul J. Coffer, Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction Nature. ,vol. 376, pp. 599- 602 ,(1995) , 10.1038/376599A0