Dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p) coordinately targeted MTDH in lung squamous cell carcinoma.

摘要: // Hiroko Mataki 1 , Naohiko Seki 2 Keiko Mizuno Nijiro Nohata 3 Kazuto Kamikawaji Tomohiro Kumamoto Keiichi Koshizuka Yusuke Goto Hiromasa Inoue Department of Pulmonary Medicine, Graduate School Medical and Dental Sciences, Kagoshima University, Kagoshima, 890-8520 Japan Functional Genomics, Chiba University Chuo-ku, 260-8670 Moores Cancer Center, California, San Diego, La Jolla, CA 92093, USA Correspondence to: Seki, email: naoseki@faculty.chiba-u.jp Keywords: microRNA-145-5p microR-145-3p tumor-suppressor, MTDH lung squamous cell carcinoma Received: June 11, 2016     Accepted: August 26, Published: September 27, 2016 ABSTRACT Patients with adenocarcinoma may benefit from recently developed molecular targeted therapies. However, analogous advanced treatments are not available for patients (lung SCC). The survival rate the stage SCC remains poor. Exploration novel oncogenic pathways might lead to new treatment protocols disease. Based on this concept, we have identified microRNA- (miRNA) mediated in SCC. It is well known that miR-145-5p (the guide strand) functions as a tumor suppressor several types cancer. impact miR-145-3p passenger cancer cells still ambiguous. Expression levels were markedly reduced tissues, ectopic expression these miRNAs inhibited aggressiveness, suggesting both acted antitumor miRNAs. We seven putative target genes ( EPN3 TPD52 CYP27B1 LMAN1 STAT1 TXNDC12 ) coordinately regulated by Among genes, found metadherin was direct Kaplan–Meier curves showed high predicted patients. investigated downstream using genome-wide gene analysis. Our data anti-apoptosis pro-proliferation involved Taken together, strands miR-145 functional play pivotal roles