Glioma Cell Invasion: Regulation of Metalloproteinase Activity by TGF-β

摘要: Matrix metalloproteinases (MMPs) are a family of extracellular endopeptidases that selectively degrade components the matrix. MMPs implicated in tumor cell invasion because they mediate breakdown basal membrane. In addition, seem to be important for creation and maintenance microenvironment facilitates survival. Among essential characteristics human malignant gliomas infiltrative growth, angiogenesis suppression antitumor immune surveillance. Transforming growth factor-beta (TGF-β) is intimately involved regulation these processes. We have previously demonstrated TGF-β promotes migration LN-18 LN-229 glioma cells via process may involve upregulation αVβ3 integrin expression. Furthermore, we defined novel pathway hepatocyte factor (HGF)-induced which requires induction TGF-β2 Here, demonstrate induces MMP-2 expression suppresses tissue inhibitor (TIMP)-2 concentration-dependently U87MG matrigel assay. Similarly, ectopic anti-apoptotic BCL-xL protein leads enhanced by cells. outline possible interrelations TGF-β, proteins BCL-2 family, integrins metalloprotease activity. By virtue its promotion regulatory immunomodulatory properties, continues one most promising targets experimental therapy glioma.