Signaling Cascades Driving the Malignant Phenotype of Glioma Cells

摘要: The most malignant brain tumor glioblastoma multiforme (GBM) is characterized by exponential growth and diffuse invasiveness. These characteristics are attributed to the varieties of common genetic lesions in genes encoding signaling proteins. DNA damages lead either activating mutations (Ras, PI3K, Akt) or loss function suppressor proteins (TP53, Rb, PTEN). pathways induced altered play a role maintenance GBM phenotype. Recent studies have elucidated various alterations critical involved GBM. This has improved our understanding cell proliferation, migration, invasion. Additionally, new exciting areas research, such as stem biology “-omics” analyses, been recently employed for studies. Many efforts now directed identification molecules gliomagenesis glioma maintenance. Signaling pathway analysis resulted novel subclassifications that could integrate with conventional histopathological features providing information regarding molecular mechanism pathogenicity. aberrant signal transduction their development progression may contribute therapeutic targets. chapter provides an overview current oncogenomics, pathways, well circuitry regulating several key cellular processes.