Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors.
作者： H Yamazaki , Y Fukui , Y Ueyama , N Tamaoki , T Kawamoto
DOI: 10.1128/MCB.8.4.1816
关键词:
摘要: By using Southern blot analysis, we found that in two cases of human glioblastoma multiforme, cells carried amplified c-erbB genes which bore short deletion mutations within the ligand-binding domain epidermal growth factor (EGF) receptor. The products these mutated were about 30 kilodalton (kDa) smaller than normal 170-kDa EGF receptor, and tumor cell membrane fractions containing 140-kDa abnormal receptor showed a significant elevation tyrosine kinase activity without its ligand. In view similarity to activated viral cellular erbB avian system, overexpressed receptors might play role onset or development cells.
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