The roles of claudin superfamily proteins in paracellular transport.

摘要: The claudin superfamily consists of at least 18 homologous proteins in humans. These are important structural and functional components tight junctions paracellular transport. Complexed with two other integral transmembrane proteins, occludin junctional adhesion molecule, claudins located both epithelial endothelial cells all junction-bearing tissues. Claudins interact directly junction-specific, membrane-associated guanylate kinase homologues, ZO-1, ZO-2, ZO-3, indirectly AF-6 the myosin-binding molecule cingulin. protein-protein interactions promote scaffolding junction provide a link to actin cytoskeleton for transducing regulatory signals from junctions. distinct permeability properties observed different epithelia endothelia seemingly result restricted tissue expression, variability homopolymer heteropolymer assembly, regulated transcription translation, subcellular localization family proteins. Defects causatively associated variety human diseases, demonstrating that play roles physiology. In conditions where cell function contributed by is essential, such as altered transport, proliferative during morphogenesis, provides molecular basis uniqueness emerges new target intervention.