Expression Profiling of Pancreatic Ductal Adenocarcinoma

摘要: Pancreatic cancer is a uniquely challenging cancer. First, it deadly the fourth leading cause of death in men and women, and, despite advances treatment other types cancer, pancreatic continues to have one highest mortality rates any malignancy. Each year U.S. approx 29,000 patients are diagnosed with will die their disease (1). The poor prognosis for is, large part, due fact that almost all at an advanced stage disease, as no known tumor markers exist could be used screen earlier, potentially curative stage. This particular problem those strong familial history who may up 57-fold greater risk developing lifetime (2,3). Second, even when mass caused by identified, can very difficult establish definitive diagnosis. Deadly infiltrating adenocarcinomas pancreas so well differentiated difficult, times impossible, distinguish from reactive changes histologically. Third, diagnosis firmly established, simply does not respond current chemotherapeutic or radiation therapies. Perhaps more than type, better understanding gene expression urgently needed.