Modelling human ageing : role of telomeres in stress-induced premature senescence and design of anti-ageing strategies

摘要: Due to the duration of human ageing, researchers must rely on models such as animals and cells. Replicative senescence stress-induced premature (SIPS) are two cellular sharing many features. Although telomeres play a major role in replicative senescence, their involvement SIPS is unclear. In this work, we first wanted investigate how accurate ageing are. We published new model evolution which offers refined view humans suggests that should be favoured. Though studying other mammals, reptiles, birds may also useful, conclude lower life forms yeast invertebrates not representative process. Secondly, elucidate importance study gene expression regulatory networks. Using telomerase-immortalized cell line, found no evidence damage specific at origin SIPS. our model, neither TGF-â1 pathway nor appear crucial suggest widespread DNA causes propose rearrangement networks result stress. Moreover, advise caution using telomerase anti-ageing therapies since alter normal functions promote tumorogenesis. Lastly, strategies integrate modern computational approaches research ageing. find it unlikely full understanding achieved within near future, argue structure finding key genes process possible.