作者: Berrylin J. Ferguson , Suchitra Paramaesvaran , Elaine Rubinstein
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摘要: Objective: To determine if rebound congestion can be reduced with concomitant nasal steroid spray usage. Study Design and Setting: Randomized, double blind, controlled single center study. Participants: Twenty subjects perennial allergic rhinitis congestion. Intervention: All received 3 weeks of twice-daily oxymetazoline. After 2 weeks, were randomized to additional budesonide aqueous (n = 9) or placebo 10). In the sixth week, all sprays stopped. Results: Both groups showed subjective objective evidence 24 hours after cessation oxymetazoline (P < 0.05). Subjective resolved in 48 group but persisted for over 1 week group. Conclusion: Rebound is objectively present patients spray. by use. Significance: This study supports common clinical practice ameliorate topical decongestant sprays. (Otolaryngol Head Neck Surg 2001;125:253-60.)