摘要: Nasal obstruction, the leading symptom of allergic rhinitis, results from combined activity early- and late-phase reactions. Desloratadine inhibits both inflammatory mediators in vitro. Thus, double-blind, placebo-controlled, randomized, crossover trials were conducted to assess efficacy desloratadine against nasal measured objectively subjectively, during controlled exposure patients with seasonal rhinitis allergen. Positive obtained in three single-dose studies; 5 mg resulted a greater improvement baseline than did placebo total score obstruction (P ≤ 0.02). was more effective multiple-dose study; given once daily for 7 days, 6-h allergen challenge administered at end treatment compared placebo. associated less deterioration mean airflow (P < 0.05) severity (P < 0.03). significantly reduces rhinitis.
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