Interaction of mercaptoundecahydrododecaborate (BSH) with phosphatidylcholine: relevance to boron neutron capture therapy

摘要: The interaction of mercaptoundecahydrododecaborate (B12H11SH2-, BSH) with phosphatidylcholine was investigated in this study order to illuminate possible uptake mechanisms BSH tumor cells. has been used clinically Japan as a boron containing agent patients malignant brain tumors for neutron capture therapy (BNCT). After infusion, accumulates selectively tissue. Little is known the mechanism Fourier transform infrared (FTIR) spectrometry quantify (at wavenumber 2490 cm-1) and 2850-2970 cm-1). extraction into carbon tetrachloride (CCl4), we could find an absorbance maximum at cm-1 B-H band mixture phosphatidylcholine, which attributed BSH-phosphatidylcholine complex, dissolve well CCl4. molar ratio CCl4 solution most one mole two moles independent excess BSH. doubly negatively charged can interact molecules through their singly positively choline residues. These ion pairs be responsible membrane binding penetration, cell internalization.