Gene variation of the transient receptor potential cation channel, subfamily M, members 6 (TRPM6) and 7 (TRPM7), and type 2 diabetes mellitus: a case-control study

摘要: Transient receptor potential cation channel, subfamily M, members 6 (TRPM6) and 7 (TRPM7), have been implicated in inflammatory disorders including diabetes, a major source of morbidity mortality developing Western society. We hypothesized that gene variation TRPM6 TRPM7 may play a role type 2 diabetes mellitus (T2DM) Using case-control population sample the Boston metropolitan area (all whites, 455 controls 467 cases), we assessed relationship 29 11 tag-single nucleotide polymorphisms (SNPs) with (1) several diabetes-related intermediate phenotypes (fasting insulin levels, fasting glucose hemoglobin A1c, homeostatic model assessment) (2) presence T2DM. All SNPs examined were Hardy–Weinberg equilibrium. Overall, genotype distributions similar between cases controls. Linear regression analysis, adjusted for risk factors/confounders, showed no evidence an association any tested aforementioned after correcting multiple testing. Marker-by-marker multivariable logistic analysis T2DM Continued investigation using entropy-blocker-defined haplotype-based approach null findings. If corroboration occurs future large prospective investigations, then present further suggests not be useful predictors assessment.