Cadmium-induced acute hepatic injury is exacerbated in human interleukin-8 transgenic mice.
作者： Hyogo Horiguchi , Akihisa Harada , Etsuko Oguma , Masao Sato , Yoshimi Homma
关键词:
摘要: It is reported repeatedly that severe hepatocellular necrosis along with infiltration of neutrophils occurs after acute cadmium exposure. Neutrophils, which migrate by the gradient chemoattractants such as interleukin-8, are believed to play an important role in inflammation at damaged sites. To investigate whether aggravate or repair liver injury induced cadmium, we checked hepatotoxic effects on human interleukin-8 transgenic mice (hIL-8Tg), overexpressed IL-8 and displayed inability neutrophil migration resulting from both lack chemotactic downregulation l-selectin surface neutrophils. A significantly lower survival rate was observed hIL-8Tg compared wild-type subcutaneous administration cadmium. Evident characterized abrupt increases plasma GOT GPT levels found 18 h administration. Histological examinations, including H & E staining esterase staining, revealed numerous into tissues mice, inhibition well enhanced hIL-8Tg. Peripheral white blood cell polymorphonuclear counts increased reached their peaks 12 whereas increase leukocyte delayed There no significant difference amounts accumulated kidneys between In conclusion, effect exacerbated inhibited migration, suggesting migrated can prevent aggravation
elsevier.com
sci-hub.se 参考文章(27)
N. Mukaida, Kouji Matsushima, S. I. Okamoto, H. Horiguchi, M. Kasuya, H. Teranishi, Cadmium induces interleukin-8 production in human peripheral blood mononuclear cells with the concomitant generation of superoxide radicals. Lymphokine and cytokine research. ,vol. 12, pp. 421- 428 ,(1993)
Kouji Matsushima, Eric T. Baldwin, Naofumi Mukaida, Interleukin-8 and MCAF: Novel Leukocyte Recruitment and Activating Cytokines (Part 1 of 2) Karger Publishers. ,vol. 51, pp. 236- 250 ,(1992) , 10.1159/000319090
Lawrence B. Schook, Debra L. Laskin, Xenobiotics and inflammation Academic Press. ,(1994)
Gunnar F Nordberg, Monica Nordberg, Bruce A Fowler, Handbook on the toxicology of metals Handbook on the toxicology of metals.. ,(2015)
H. M. Mehendale, R. A. Roth, A. Jay Gandolfi, J. E. Klaunig, John J. Lemasters, L. R. Curtis, Novel mechanisms in chemically induced hepatotoxicity. The FASEB Journal. ,vol. 8, pp. 1285- 1295 ,(1994) , 10.1096/FASEBJ.8.15.8001741
Robert E. Dudley, Donald J. Svoboda, Curtis D. Klaassen, Acute exposure to cadmium causes severe liver injury in rats Toxicology and Applied Pharmacology. ,vol. 65, pp. 302- 313 ,(1982) , 10.1016/0041-008X(82)90013-8
R. L. Brinster, H. Y. Chen, M. E. Trumbauer, M. K. Yagle, R. D. Palmiter, Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 4438- 4442 ,(1985) , 10.1073/PNAS.82.13.4438
J LIU, Endotoxin induction of hepatic metallothionein is mediated through cytokines*1 Toxicology and Applied Pharmacology. ,vol. 109, pp. 235- 240 ,(1991) , 10.1016/0041-008X(91)90171-A
W S Simonet, T M Hughes, H Q Nguyen, L D Trebasky, D M Danilenko, E S Medlock, Long-term impaired neutrophil migration in mice overexpressing human interleukin-8. Journal of Clinical Investigation. ,vol. 94, pp. 1310- 1319 ,(1994) , 10.1172/JCI117450
Stamatios E. Theocharis, Vassilios L. Souliotis, Panayiotis G. Panayiotidis, Suppression of interleukin-1β and tumour necrosis factor-α biosynthesis by cadmium in in vitro activated human peripheral blood mononuclear cells Archives of Toxicology. ,vol. 69, pp. 132- 136 ,(1994) , 10.1007/S002040050148