Components of ubiquitin ligase complexes and uses related thereto
作者： Maureen Caligiuri , Mark Rolfe
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摘要: The present invention relates to the isolation of a new class ubiquitin ligases involved in protein degradation vertebrate organisms, such as cell cycle regulatory proteins. Accordingly, provides nucleic acids and proteins encoded by said which play role ubiquitinylation subsequent substrate regulating proliferation, differentiation, survival. also methods for modulating degradation, differentiation and/or survival ubiquitination; assays identifying compounds modulate survival; treating disorders associated with aberrant diagnostic prognostic determining whether subject is at risk developing disorder an
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