Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins.

作者： M Scheffner , T Takahashi , J M Huibregtse , J D Minna , P M Howley

DOI: 10.1128/JVI.66.8.5100-5105.1992

关键词: Protein biosynthesis 、 Biology 、 Binding site 、 Gene product 、 Proteolysis 、 Amino acid 、 Wild type 、 Cell biology 、 Mutant 、 Peptide sequence 、 Molecular biology 、 Immunology 、 Insect Science 、 Microbiology 、 Virology

摘要: The E6 oncoproteins encoded by the cancer-associated human papillomaviruses (HPVs) can associate with and promote the degradation of wild-type p53 in vitro. To gain further …