Interactions Between Papillomavirus Proteins and Tumor Suppressor Gene Products

摘要: Publisher Summary Human papillomaviruses (HPVs) have provided unique insight into the mechanisms that regulate growth and oncogenic progression of human cells. The genital HPV types cause lesions are not strictly benign; malignant HPV-infected cells appears to give rise almost all cervical cancers. paradigm for tumor suppressor genes has now been joined by a growing number whose loss function contributes cancer development; subsequently, many these shown play role in preventing or delaying progress through cell cycle. Studies somatic mutation within loci frequently development sporadic Several cell-encoded proteins detected association with viral E6 E7, identification some as products revealed at least oncoprotein function. Viral oncoproteins identified enormous advances unraveling their mechanism action participated convergence different areas research. application understanding interactions between host directly treating such common disease may be fitting culmination studies.