Antiviral Effects of Novel Herbal Medicine KIOM-C, on Diverse Viruses
作者： Jong-Soo Lee Mohammed Y. E. Chowdhury , Melbourne R. Talactac , Min-Eun Park , Prasanna Weeratunga , Tae-Hwan Kim
DOI: 10.1371/JOURNAL.PONE.0125357
关键词:
摘要: In order to identify new potential antiviral agents, recent studies have advocated thorough testing of herbal medicines or natural substances that are traditionally used prevent viral infections. Antiviral activities and the mechanism action total aqueous extract preparation KIOM-C, a novel medicine, against diverse types viruses were investigated. vitro activity A/Puerto Rico/8/34 (H1N1) (PR8), vesicular stomatitis virus (VSV), Newcastle disease (NDV) through induction type-I interferon related protein phosphorylation up-regulation pro-inflammatory cytokines in murine macrophage cells (RAW264.7) determined. vivo, KIOM-C-treated BALB/c mice showed higher survivability lower lung titers when challenged with A/Aquatic bird/Korea/W81/2005 (H5N2), A/PR/8/34(H1N1), bird/Korea/W44/2005(H7N3) A/Chicken/Korea/116 /2004(H9N2) influenza subtypes contrast non-treated group. The present study revealed KIOM-C stimulates an state leading inhibition infection protection lethal challenges.
core.ac.uk
mendeley.com
harvard.edu参考文章(51)
Pongsri Tongtawe, Wanpen Chaicumpa, Thaweesak Songserm, Pramuan Tapchaisri, Santi Maneewatch, Umaporn Thathaisong, Kanyarat Thueng-In, Jeeraphong Thanongsaksrikul, Kasem Kulkeaw, Potjanee Srimanote, Human single-chain antibodies that neutralize homologous and heterologous strains and clades of influenza A virus subtype H5N1 Antiviral Therapy. ,vol. 14, pp. 221- 230 ,(2009)
Ge HU, Jiu-zhou XUE, Jing LIU, Tao ZHANG, Hong DONG, Hui-qin DUAN, Zuo-jun YANG, Xiao-ming REN, Xiang MU, Baicalin Induces IFN-α/β and IFN-γ Expressions in Cultured Mouse Pulmonary Microvascular Endothelial Cells Journal of Integrative Agriculture. ,vol. 11, pp. 646- 654 ,(2012) , 10.1016/S2095-3119(12)60052-5
V. Umapathi, T. Ambwani, M. Pant, Antiviral Activity of Ashwagandha Extract on Infectious Bursal Disease Virus Replication Indian journal of science and technology. ,vol. 5, pp. 2750- 2751 ,(2012) , 10.17485/IJST/2012/V5I5/30455
Ruimei Li, Binghe Tan, Yan Yan, Xiaobin Ma, Na Zhang, Zhi Zhang, Mingyao Liu, Min Qian, Bing Du, Extracellular UDP and P2Y6 Function as a Danger Signal To Protect Mice from Vesicular Stomatitis Virus Infection through an Increase in IFN-β Production Journal of Immunology. ,vol. 193, pp. 4515- 4526 ,(2014) , 10.4049/JIMMUNOL.1301930
Bao Qun Li, Tao Fu, Yao Dongyan, Judy A. Mikovits, Francis W. Ruscetti, Ji Ming Wang, FLAVONOID BAICALIN INHIBITS HIV-1 INFECTION AT THE LEVEL OF VIRAL ENTRY Biochemical and Biophysical Research Communications. ,vol. 276, pp. 534- 538 ,(2000) , 10.1006/BBRC.2000.3485
Osamu Takeuchi, Shizuo Akira, Recognition of viruses by innate immunity Immunological Reviews. ,vol. 220, pp. 214- 224 ,(2007) , 10.1111/J.1600-065X.2007.00562.X
Cristina Puig-Saus, Alena Gros, Ramon Alemany, Manel Cascalló, Adenovirus i-Leader Truncation Bioselected Against Cancer-associated Fibroblasts to Overcome Tumor Stromal Barriers Molecular Therapy. ,vol. 20, pp. 54- 62 ,(2012) , 10.1038/MT.2011.159
K DROEBNER, C EHRHARDT, A POETTER, S LUDWIG, O PLANZ, CYSTUS052, a polyphenol-rich plant extract, exerts anti-influenza virus activity in mice. Antiviral Research. ,vol. 76, pp. 1- 10 ,(2007) , 10.1016/J.ANTIVIRAL.2007.04.001
Kathryn V Anderson, Toll signaling pathways in the innate immune response. Current Opinion in Immunology. ,vol. 12, pp. 13- 19 ,(2000) , 10.1016/S0952-7915(99)00045-X
AEYUNG KIM, NAM-HUI YIM, MINJU IM, YOUNG PIL JUNG, TAESOO KIM, JIN YEUL MA, Suppression of the invasive potential of highly malignant tumor cells by KIOM-C, a novel herbal medicine, via inhibition of NF-κB activation and MMP-9 expression. Oncology Reports. ,vol. 31, pp. 287- 297 ,(2014) , 10.3892/OR.2013.2822