Ultrastructural changes to the palatal mucosa of rats following the application of 4-nitroquinoline-1-oxide (4NQO) and vitamin C
作者： S.V. Kandarkar , S.S. Sawant , P.C. Reade
DOI: 10.1016/S1368-8375(98)80002-X
关键词:
摘要: Oral mucosal neoplastic disease in rodents has been induced by various chemical carcinogens, including water soluble 4-nitro-quinoline-1-oxide (4NQO). It suggested that vitamin C can inhibit, delay or prevent the development of neoplasms, as well enhance induction neoplasia. In this investigation, 4NQO was used to produce a high yield carcinomas palatal mucosa rats relatively short period time and topical applied transformation. The temporal aspects ultrastructural changes occurring 4NQO-induced oral treated with both have described discussed.
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