Electron microscopic changes on the DMBA induced oral precancerous and cancerous lesion in hamster cheek pouch.
作者： SV Kandarkar , PS Gijare , KVK Rao , SV Bhide , None
DOI: 10.1016/0309-1651(91)90102-O
关键词:
摘要: Abstract Experiments were performed to study the early and late ultrastructural changes during hamster cheek pouch carcinogenesis using a regimen of topical application 9, 10 dimethyl-1-2 benzanthracene (DMBA) twice week in liquid paraffin oil. The DMBA was administered for period 2 4 1 months. Hamsters exposed months developed moderate precancerous changes, whereas hamsters treated with frank multiple oral tumors cauliflower appearance. pathological seen considerably increased at compared month treatment. Untreated solvant control oil alone did not show any premalignant or malignant this period.
sci-hub.se 参考文章(16)
Rajani A. Bhisey, Satyavati M. Sirsat, Ultrastructural analysis of epidermal hyperplasia induced by multiple 12-0-tetradecanoyl-phorbol-13-acetate (TPA) treatment of mouse skin. Tumori. ,vol. 72, pp. 643- 650 ,(1986) , 10.1177/030089168607200618
S. V. Kandarkar, S. M. Sirsat, Periodic histopathological and ultrastructural changes of excess vitamin A on oral carcinogenesis. Indian Journal of Experimental Biology. ,vol. 28, pp. 10- 17 ,(1990)
Jens Jörgen Pindborg, Oral cancer and precancer J. Wright. ,(1980)
Alberto N. Raick, Ultrastructural, Histological, and Biochemical Alterations Produced by 12-O-Tetradecanoyl-phorbol-13-acetate on Mouse Epidermis and Their Relevance to Skin Tumor Promotion Cancer Research. ,vol. 33, pp. 269- 286 ,(1973)
D.A. Woods, C.J. Smith, Ultrastructure of the Dermal-epidermal Junction in Experimentally Induced Tumors and Human Oral Lesions**From the Electron Microscopy Unit, Imperial Cancer Research Fund, London, WC2. Journal of Investigative Dermatology. ,vol. 52, pp. 259- 263 ,(1969) , 10.1038/JID.1969.40
Inhibition of Oral Carcinogenesis by a Protease Inhibitor Journal of the National Cancer Institute. ,vol. 76, pp. 447- 452 ,(1986) , 10.1093/JNCI/76.3.447
M.P. Marefat, J.T. Albright, G. Shklar, Ultrastructural alterations in experimental lingual leukoplakia and carcinoma. Oral Surgery, Oral Medicine, Oral Pathology. ,vol. 47, pp. 334- 342 ,(1979) , 10.1016/0030-4220(79)90256-1
PS Gijare, KVK Rao, SV Kandarkar, SV Bhide, None, Enhanced expression of tonofilament bundles during hamster cheek pouch carcinogenesis is associated with tumour growth and the loss of high molecular weight keratins. Cell Biology International Reports. ,vol. 12, pp. 1067- 1075 ,(1988) , 10.1016/0309-1651(88)90031-8
F. H. White, K. Gohari, A qualitative ultrastructural study of the intercellular spaces between epithelial cells treated in vivo with DMBA. Journal of Oral Pathology & Medicine. ,vol. 13, pp. 231- 243 ,(1984) , 10.1111/J.1600-0714.1984.TB01421.X
Sirsat Sm, Kandarkar Sv, Changes in vitamin A conditioned hamster cheek pouch epithelium on exposure to commercial shell lime (calcium hydroxide) and tobacco-II ultrastructure. Indian Journal of Cancer. ,vol. 15, pp. 14- ,(1978)