Hypoxia-reoxygenation differentially stimulates stress-activated protein kinases in primary-cultured rat hepatocytes
作者： D. Crenesse , A. Schmid-Alliana , J. Hornoy , B. Rossi , J. Gugenheim
关键词:
摘要: Organ injury after ischemia and reperfusion (I/R) remains one of the most important limiting factors in liver surgery transplantation. Oxygen-free radical (OFR) generation is considered a major cause this damage. JNK1/SAPK1, member MAPK family, regulates cell adaptation to stressful conditions. The aim study was determine if hypoxia-reoxygenation (H/R) can activate JNK1/SAPK1 OFR are involved activation. Primary cultured rat hepatocytes isolated from other cells blood flow were submitted warm cold H/R phases mimicking surgical transplant activated by both H/R. Deferoxamine (1 mM), di-phenyleneiodonium (50 μM) N-acetylcysteine (10 mM) significantly inhibited kinase
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