Crosstalk between p38, Hsp25 and Akt in spinal motor neurons after sciatic nerve injury.
作者： Alexander K Murashov , Ihtsham Ul Haq , Charles Hill , Eunice Park , Michael Smith
DOI: 10.1016/S0169-328X(01)00212-1
关键词:
摘要: The p38 stress-activated protein kinase pathway is involved in regulation of phosphorylation Hsp25, which turn regulates actin filament dynamic non-neuronal cells. We report that p38, Hsp25 and Akt signaling pathways were specifically activated spinal motor neurons after sciatic nerve axotomy. activation the was required for induction expression. Furthermore, formed a complex with Akt, member PI-3 prevents neuronal cell death. Together, our observations implicate as central player system may both promote regeneration fibers prevent death injured cord.
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