ACEMETACIN ANTINOCICEPTIVE MECHANISM IS NOT RELATED TO NO OR K + CHANNEL PATHWAYS.
作者： M Gil-Flores , MI Ortiz , G Castañeda-Hernández , Aracely Evangelina Chavez-Piña , None
DOI: 10.1358/MF.2010.32.2.1423883
关键词:
摘要: SUMMARY Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of acute gout and inflammation. However, its use limited due to side effects. Acemetacin prodrug indomethacin that exhibits better gastric tolerability in preclinical clinical trials. The aim this study was examine if systemic administration acemetacin involved sequential participation nitric oxide (NO) or K + channel pathways confer antinociceptive effect, as compared indomethacin. effect both drugs studied with formalin test. Equimolar doses were administered orally. intraplantar either L-NAME, glibenclamide, apamin charybdotoxin plus using test antihyperalgesic effects measured. not significantly different when pretreatment done. antiinflammatory also similar acemetacin. Our results suggest mediated by NO activation.
sci-hub.st 参考文章(24)
B.F. Leeb, L. Bucsi, B. Keszthelyi, J. B�hmova, M. Valesova, R. Hawel, F. Mayrhofer, F. Singer, F. Aglas, H. Br�ll, Treatment of osteoarthritis of the knee joint. Efficacy and tolerance to acemetacin slow release in comparison to celecoxib Orthopade. ,vol. 33, pp. 1032- 1041 ,(2004) , 10.1007/S00132-004-0670-Z
Jorge Olguín Uribe, Arturo Torres y Gutierrez Rubio, Luis Eduardo Herrera Gómez, Gerardo Bori Segura, Efficacy and tolerability of acemetacin, a non-steroidal anti-inflammatory drug, in Mexican patients : result of the ETAPAM Study Proceedings of the Western Pharmacology Society. ,vol. 45, pp. 104- 107 ,(2002)
Vidal-Cantú Gc, Castañeda-Hernández G, Rosas R, Ortiz Mi, Granados-Soto, Torres-López Je, Role of the nitric oxide-cyclic GMP-K+ channel pathway in the antinociception induced by atrial natriuretic peptide (ANP) and diclofenac. Proceedings of the Western Pharmacology Society. ,vol. 45, pp. 174- ,(2002)
M. ZIMMERMANN, G. D. BARTOSZYK, D. BONKE, I. JURNA, A. WILD, Antinociceptive Properties of Pyridoxine Annals of the New York Academy of Sciences. ,vol. 585, pp. 219- 230 ,(1990) , 10.1111/J.1749-6632.1990.TB28055.X
Helen Wheeler-Aceto, Alan Cowan, STANDARDIZATION OF THE RAT PAW FORMALIN TEST FOR THE EVALUATION OF ANALGESICS Psychopharmacology. ,vol. 104, pp. 35- 44 ,(1991) , 10.1007/BF02244551
J. R. VANE, Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs Nature. ,vol. 231, pp. 232- 235 ,(1971) , 10.1038/NEWBIO231232A0
K. Hargreaves, R. Dubner, F. Brown, C. Flores, J. Joris, A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. ,vol. 32, pp. 77- 88 ,(1988) , 10.1016/0304-3959(88)90026-7
S. H. FERREIRA, Prostaglandins, aspirin-like drugs and analgesia. Nature. ,vol. 240, pp. 200- 203 ,(1972) , 10.1038/NEWBIO240200A0
Jeremy N. Cashman, The Mechanisms of Action of NSAIDs in Analgesia Drugs. ,vol. 52, pp. 13- 23 ,(1996) , 10.2165/00003495-199600525-00004
Carlos Rogério Tonussi, Sérgio H. Ferreira, Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization European Journal of Pharmacology. ,vol. 251, pp. 173- 179 ,(1994) , 10.1016/0014-2999(94)90398-0