Computational assessment of drug‐induced effects on the electrocardiogram: from ion channel to body surface potentials

摘要: This work is based on the computational models describing physiology of electrical wave propagation in heart. The goal to show ability reproduce effect drugs activity heart at cell, organ (heart) and ECG body surface potential levels. We use state-of-the-art mathematical governing activity. drug model introduced using an ion channel conductance block for both hERG sodium depending IC50 value dose. measure compare different biomarkers. Introducing a 50% results 7.8% prolongation APD90 5.7% QT interval prolongation, whereas does not affect QRS interval. prolongs intervals respectively by 12% 5% delays activation times, APD90. Both potassium blocks prolong interval, but reason behind different: For first it due APD while second reduction velocity. example study shows usability silco investigation mechanism assessment side effects.