Finding the Rhythm of Sudden Cardiac Death: New Opportunities Using Induced Pluripotent Stem Cell–Derived Cardiomyocytes

摘要: Sudden cardiac death is a common cause of in patients with structural heart disease, genetic mutations, or acquired disorders affecting ion channels. A wide range platforms exist to model and study associated sudden death. Human clinical studies are cumbersome thwarted by the extent investigation that can be performed on human subjects. Animal models limited their degree homology electrophysiology, including channel expression. Most commonly used cellular transfection models, which able mimic expression single-ion offering incomplete insight into changes action potential profile. Induced pluripotent stem cell–derived cardiomyocytes resemble, but not identical, adult provide new platform for studying arrhythmic leading variety phenotype conventional automated patch clamp, multielectrode array, computational modeling. have been long QT syndrome, catecholaminergic polymorphic ventricular tachycardia, hypertrophic cardiomyopathy, other hereditary disorders. Although induced distinct from cardiomyocytes, they robust advance science care