Mutagenicity of some indoles and related compounds in the Ames test.
作者： Margareta Curvall , Inger Florin , Tommy Jansson
DOI: 10.1016/0300-483X(82)90036-1
关键词:
摘要: A series of indole derivatives and some analogues were tested for mutagenic activity using a histidine-requiring mutant Salmonella typhimurium (TA 98). Quantitative tests performed with without addition liver fraction (S-9) from rats induced Aroclor 1254. Three compounds, 2,3-dimethylindole, 2,3,5-trimethylindole 2,3,6-trimethylindole, showed effect which was not increased on metabolic activation. The influence the number positions substituents attached to skeleton is discussed.
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sci-hub.se 参考文章(13)
Bruce N. Ames, Joyce McCann, Edith Yamasaki, Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test Mutation Research. ,vol. 31, pp. 347- 364 ,(1975) , 10.1016/0165-1161(75)90046-1
Takashi Matsumoto, Daisuke Yoshida, Hideo Tomita, Determination of mutagens, amino-α-carbolines in grilled foods and cigarette smoke condensate Cancer Letters. ,vol. 12, pp. 105- 110 ,(1981) , 10.1016/0304-3835(81)90045-8
Monica Thelestam, Margareta Curvall, Curt R. Enzell, Effect of tobacco smoke compounds on the plasma membrane of cultured human lung fibroblasts Toxicology. ,vol. 15, pp. 203- 217 ,(1980) , 10.1016/0300-483X(80)90054-2
Pierre Lecointe, Pierre Lesca, Suzy Cros, Claude Paoletti, Some antitumor derivatives of ellipticine deprived of mutagenic properties. Chemico-Biological Interactions. ,vol. 20, pp. 113- 121 ,(1978) , 10.1016/0009-2797(78)90086-8
Hiroko Tohda, Atsushi Oikawa, Takashi Kawachi, Takashi Sugimura, Induction of sister-chromatid exchanges by mutagens from amino acid and protein pyrolysates Mutation Research\/genetic Toxicology. ,vol. 77, pp. 65- 69 ,(1980) , 10.1016/0165-1218(80)90121-4
Inger Florin, Lars Rutberg, Margareta Curvall, Curt R. Enzell, Screening of tobacco smoke constituents for mutagenicity using the Ames' test. Toxicology. ,vol. 15, pp. 219- 232 ,(1980) , 10.1016/0300-483X(80)90055-4
J. Fitzpatrick, R. Hiser, Notes - Noncatalytic Fischer Indole Synthesis Journal of Organic Chemistry. ,vol. 22, pp. 1703- 1704 ,(1957) , 10.1021/JO01363A611
Bertil Pettersson, Margareta Curvall, Curt R. Enzell, Effects of tobacco smoke compounds on the noradrenaline induced oxidative metabolism in isolated brown fat cells. Toxicology. ,vol. 18, pp. 1- 15 ,(1980) , 10.1016/0300-483X(80)90033-5
Bertil Petersson, Margareta Curvall, Curt R. Enzell, Effects of tobacco smoke compounds on the ciliary activity of the embryo chicken trachea in vitro Toxicology. ,vol. 23, pp. 41- 55 ,(1982) , 10.1016/0300-483X(82)90040-3
Ake Pilotti, Klas Ancker, Erik Arrhenius, Curt Enzell, Effects of tobacco and tobacco smoke constituents on cell multiplication in vitro Toxicology. ,vol. 5, pp. 49- 62 ,(1975) , 10.1016/0300-483X(75)90069-4