Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.
作者： Masahiro Yamamoto , Shintaro Sato , Kiyotoshi Mori , Katsuaki Hoshino , Osamu Takeuchi
DOI: 10.4049/JIMMUNOL.169.12.6668
关键词:
摘要: MyD88 is a Toll/IL-1 receptor (TIR) domain-containing adapter common to signaling pathways via Toll-like (TLR) family. However, accumulating evidence demonstrates the existence of MyD88-independent pathway, which may explain unique biological responses individual TLRs, particularly TLR3 and TLR4. TIR protein (TIRAP)/MyD88 adapter-like, second harboring domain, essential for MyD88-dependent TLR2 TLR4 pathways, but not pathways. Here, we identified novel molecule, named inducing IFN-beta (TRIF). As case in TIRAP, overexpression TRIF activated NF-kappaB-dependent promoter. A dominant-negative form inhibited TLR2-, TLR4-, TLR7-dependent NF-kappaB activation. Furthermore, TRIF, neither nor Dominant-negative TLR3-dependent activation both promoters. associated with IFN regulatory factor 3. These findings suggest that involved TLR signaling, pathway.
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