East Asian genotypes of Helicobacter pylori strains in Amerindians provide evidence for its ancient human carriage.

作者: C. Ghose , G. I. Perez-Perez , M.-G. Dominguez-Bello , D. T. Pride , C. M. Bravi

DOI: 10.1073/PNAS.242574599

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摘要: Phylogenies of indigenous microbes have been used as surrogates for the origins hosts that carry them. Conversely, polymorphisms may be to date spread a microbial species when information about their host populations is available. Therefore, we examined in Helicobacter pylori, which persistently colonize human stomach, test hypothesis they ancient inhabitants humans. Three H. pylori loci previously shown phylogeographic affinity analyzed two with different ethnic from Venezuela. In group Amerindian subjects Amazonia, East Asian genotypes were present each but absent mestizo population Caracas. These findings provide evidence has humans at least since ancestors Amerindians migrated Asia more than 11,000 years ago.

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