Substance P is associated with hypothalamic paraventricular nucleus activation that coincides with increased urotensin 2 mRNA in chicks
作者： Jacob D. Mace , Tetsuya Tachibana , Guoqing Wang , Brandon A. Newmyer , Evin Guilliams
DOI: 10.1016/J.NPEP.2014.06.001
关键词:
摘要: Exogenous administration of substance P (SP) exerts anorexigenic effects in both chicks and rats, but the central mechanism mediating this response is poorly understood. Therefore, study was designed to elucidate mechanisms SP-induced anorexia using as models. Chicks that received intracerebroventricular (ICV) injections SP dose-dependably reduced their food intake with no effect on water intake. Next, diencephalon isolated from SP-injected mRNA expression neuropeptide Y (NPY), corticotropin releasing factor (CRF), urocortin 3 (UCN 3) CRF receptors were measured not affected. When hypothalamus, abundance these NPY receptors, urotensin 2 (UTS2) melanocortin receptor 4 (MCR4) affected by SP-injection. Quantification c-Fos immunoreactivity appetite-associated hypothalamic nuclei demonstrated paraventricular nucleus (PVN) activated chicks. Finally, PVN chicks, there increased UTS2 while UCN3 Thus, appear be mediated activation may involve UTS2.
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