Left ventricular dyssynchrony assessment by phase analysis from gated PET-FDG scans
作者： Aju P. Pazhenkottil , Ronny R. Buechel , Rene Nkoulou , Jelena-Rima Ghadri , Bernhard A. Herzog
DOI: 10.1007/S12350-011-9411-Y
关键词:
摘要: The outcome of patients with severe ischaemic left ventricular (LV) dysfunction is determined by the extent myocardial viability and presence LV dyssynchrony. We aimed at assessing both parameters from same imaging method, i.e. gated positron emission tomography (PET) F18-fluorodeoxyglucose (FDG) scans. Phase analysis Emory Cardiac Toolbox was applied on PET-FDG scans to assess histogram bandwidth standard deviation (SD) as a measure dyssynchrony in 30 heart failure (mean ejection fraction: 30.2% ± 13.8%) referred for evaluation viability. Cut-off values single-photon computed perfusion (SPECT-MPI) best predicting cardiac resynchronization therapy (CRT) response served reference (bandwidth < 135°; phase SD < 43°). Severe diagnosed if SPECT-MPI were above these limits. Intraclass correlation clinical agreement detection PET vs SPECT assessed. There significant between (r = 0.88, P < .001) SD resulting an excellent two methods 93%. Accurate assessment feasible, allowing one scan.
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