Severe left ventricular dyssynchrony is associated with poor prognosis in patients with moderate systolic heart failure undergoing coronary artery bypass grafting.

摘要: Objectives The objective of the present study was to assess relationship between presence left ventricular (LV) dyssynchrony and clinical outcome in patients with moderate systolic heart failure undergoing coronary artery bypass graft (CABG) surgery. Background LV is associated poor prognosis dysfunction. Methods consisted 215 consecutive ischemic cardiomyopathy dyspnea (age 65 ± 9 years, 81% male) CABG. Dyssynchrony calculated by tissue Doppler imaging from regional time intervals basal segments before 1 month after Myocardial viability assessed using single-photon emission computed tomography (SPECT) Results Twenty-five (11.6%) died within 30 days (in-hospital mortality) pre-CABG ≥119 ms had highest predictive accuracy for in-hospital mortality, a sensitivity 84% specificity 71%. During median follow-up period 359 (interquartile range 219 561), an additional 19 (10.3%) 34 (18.5%) were hospitalized worsening failure. At Cox regression analysis, post-CABG ≥72 ≥5 viable identified as independent predictors events, hazard ratio (HR) 5.02, 95% confidence interval (CI) 2.57 10.02 (p Conclusions severe outcomes despite revascularization. These results advocate routine assessment both predict CABG