Vascular hypertrophy and albumin permeability in a rat model combining hypertension and diabetes mellitus. Effects of calcium antagonism, angiotensin converting enzyme inhibition, and angiotensin II-AT1-receptor blockade.
作者： U Lennart Hulthén , Zemin Cao , Jonathan R Rumble , Mark E Cooper , Colin I Johnston
DOI: 10.1016/S0895-7061(96)00177-X
关键词:
摘要: The aim of this study was to compare the effects angiotensin converting enzyme (ACE) inhibition, II (AII) AT1-receptor blockade, and dihydropyridine calcium antagonism on hypertrophy vascular albumin permeability in kidney, heart, mesenteric artery a model combining genetic hypertension diabetes mellitus. Diabetes mellitus induced by streptozotocin 8-week-old spontaneously hypertensive rats. animals were randomized receive no treatment, inhibitor ramipril, AII blocker valsartan, or antagonist lacidipine for 3 weeks. Vascular measured as tissue content intravenously injected Evans blue dye (EB) tissue/plasma EB ratio calculated. Systolic blood pressure reduced all three antihypertensive regimens. Glycemic control similar diabetic groups. Kidney not affected any drugs. Hypertrophy enhanced but ramipril valsartan. Relative heart weight also increased lacidipine. permeability, expressed micrograms/gram dry ratio, higher kidneys lacidipine-treated rats than other group There positive correlation between kidney weight/body kidney/plasma These findings indicate that is associated with an unfavorable effect Furthermore, there seems be coupling permeability.
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