Early Use of Daptomycin Versus Vancomycin for Methicillin-Resistant Staphylococcus aureus Bacteremia With Vancomycin Minimum Inhibitory Concentration >1 mg/L: A Matched Cohort Study

摘要: Background Recent reports have described decreased effectiveness with vancomycin treatment for methicillin-resistant Staphylococcus aureus bacteremia (MRSAB) when the minimum inhibitory concentration (MIC) is >1 µg/mL. Methods This matched, retrospective cohort study compared clinical of daptomycin that MRSAB MICs The primary outcome was failure, defined as a composite 30-day mortality or persisting ≥7 days. Results One hundred seventy patients were matched 1:1 respect to antimicrobial administered. In group, all received Conclusions first comparing early versus MIC Treatment resulted in significantly improved outcomes, including and persistent bacteremia. These results support practice switching from