The Clinical Pharmacology of Filgrastim and Pegfilgrastim
作者： Lorin K. Roskos
DOI: 10.1007/978-3-0348-0218-5_4
关键词:
摘要: Granulocyte colony-stimulating factor (G-CSF), an endogenous hematopoietic growth factor, selectively stimulates granulopoietic cells of the neutrophil lineage [1]. G-CSF increases proliferation and differentiation progenitor cells, induces maturation enhances survival function mature neutrophils [2, 3]. Filgrastim is a recombinant methionyl form human (r-metHuG-CSF) produced in Escherichia coli has been approved for treatment neutropenia cancer patients receiving myelosuppressive chemotherapy, with acute myeloid leukemia (AML) induction or consolidation myeloablative chemotherapy followed by bone marrow transplantation, severe chronic neutropenia; filgrastim also mobilization undergoing peripheral blood cell (PBPC) collection therapy
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