Selective differences in macrophage populations and monokine production in resolving pulmonary granuloma and fibrosis.

摘要: Alveolar macrophages (AM) and their production of interleukin-1-like activity (IL-1) macrophage-derived growth factor for fibroblasts (MDGF) were examined during chronic inflammatory reactions leading to either granuloma formation or fibrosis. Groups five rats each received, respectively, a single transtracheal injection xonotlite, attapulgite, short chrysotile 4T30, UICC B asbestos, saline. One month later, such treatments induced no change (xonotlite), (attapulgite 4T30), fibrosis (UICC B). By 8 months, however, the granulomatous had resolved greatly diminished, whereas persisted irreversibly. Parallel examination cell populations obtained by bronchoalveolar lavage revealed that multinucleated giant (MGC) present in fluids animals with resolving but absent those from lung Evaluation monokine also significant differences. Enhanced IL-1-like was seen both types injury, although especially early stage (1 month) decreased thereafter (8 months). contrast, augmentation MDGF observed only up 9 months. Taken together, these data indicate selected cytokines, as well AM differentiation along given pathway, may modulate outcome response.