Role of Ion Channels and Amino-Acid Transporters in the Biology of Astrocytic Tumors

摘要: The malignant transformation of central nervous system (CNS) glial cells gives rise to tumors that are collectively called gliomas. Although the vast majority these cancers believed be astrocytic origin, actual cell origin remains unknown. While gliomas present with many same genetic alterations in tumor suppressor genes or oncogenes common amongst cancers, their biology differs quite significantly from other neoplasms. Importantly, growth is limited by size skull, and hence expansion can only occur when normal brain destroyed. Recent research suggests accomplish this releasing glutamate at concentrations cause excitotoxic neuronal death. Peritumoral may also contribute seizures, which a comorbidity patients glioma. Another differentiating feature unusual ability spread diffusely invading tissue rather than through hematogenous routes as for most cancers. Glioma migration narrow extracellular spaces often occurs along blood vessels nerve fiber tracts requires undergo profound changes