Development of a Metal‐Ion‐Mediated Base Pair for Electron Transfer in DNA
作者： Thomas Ehrenschwender , Wolfgang Schmucker , Christian Wellner , Timo Augenstein , Patrick Carl
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摘要: A new C-nucleoside structurally based on the hydroxyquinoline ligand was synthesized that is able to form stable pairs in DNA both absence and presence of metal ions. The interactions between centers adjacent CuII-mediated base were probed by electron paramagnetic resonance (EPR) spectroscopy. metal-metal distance falls into range previously reported values. Fluorescence studies with a donor-DNA-acceptor system indicate photoinduced charge-transfer processes across these metal-ion-mediated occur more efficiently than over natural pairs. Ace base: duplex stability can be significantly increased coordinating CuII ions (metal-mediated pairing; see scheme).
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