p53: Pro-aging or pro-longevity?

摘要: p53 continues to surprise biologists. For nearly a decade, it was thought be an oncogene [1,2], only subsequently declared potent tumor suppressor [3,4]. Initially characterized as transcriptional activator, we now know is also repressor [5]. And just seemed activities were confined the nucleus, became apparent that functioned in cytoplasm regulate mitochondrial responses [6,7]. As and regulator of hundreds genes [5], perhaps not surprising shown numerous cellular processes related cancer -- cell cycle progression, apoptosis, senescence DNA repair, among others. It another surprise, however, learn might aging.