Early myelin lesions in experimental allergic neuritis.

摘要: We examined the evolution of demyelination in spinal roots Lewis rats immunized with whole nerve and complete Freund's adjuvant. Roots were morphologically normal until 11 days after immunization, when we found endoneurial edema myelin vesiculation absence mononuclear cell contacts. Macrophage-associated stripping was not detected day 12. Macrophage infiltrations extensive by 14, but lymphocytes sparse. These observations indicate that experimental allergic neuritis, injury may occur before macrophage-mediated demyelination, provide support for an early role serum factors development this disorder.