Transient respiratory response to hypercapnia: Analysis via a cardiopulmonary simulation model

摘要: In recent years, our group has developed a comprehensive cardiopulmonary (CP) model that comprises the heart, systemic and pulmonary circulations, lung mechanics gas exchange, tissue metabolism, cardiovascular respiratory control mechanisms. this paper, we analyze response of to hypercapnic conditions hence focus on chemoreflex mechanism. Particularly, have enhanced peripheral chemoreceptor in order better reflect physiology. Using CO 2 fraction inspired air as input CP model, were able transient system step at different levels, terms alveolar partial pressures, tidal volume, minute ventilation frequency. Model predictions tested against experimental data from human subjects [1]. Results show good agreement for all variables under study during phases low root mean square errors steady state. This indicates potential be used valid tool clinical practice medical research, providing complementary way experience-based decisions.