A theoretical analysis of the carotid body chemoreceptor response to O2 and CO2 pressure changes.
作者： Mauro Ursino , Elisa Magosso
DOI: 10.1016/S0034-5687(01)00335-8
关键词: Chemoreceptor 、 Stimulus (physiology) 、 Oxygene 、 Oxygen 、 Time derivative 、 Carotid body 、 Thermodynamics 、 Saturation (chemistry) 、 Arterial blood 、 Anatomy 、 Chemistry
摘要: A simple mathematical model of the carotid body chemoreceptor response is presented. The model assumes that the static chemoreceptor characteristic depends on oxygen saturation in the arterial blood and on CO2 arterial concentration. The values of O2 saturation and of CO2 concentration are computed, from pressure, using blood dissociation curves, which include both the Bohr and Haldane effects. Moreover, the O2–CO2 static responses interact via a multiplicative term followed by an upper saturation. The dynamic response includes a …
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