14 A flexible, iterative approach to physiological modelling

摘要: Publisher Summary This chapter explores some of the issues that arise when modeling physiology with a view to constructing medically useful models. Some from concrete work on specific system—the cerebral circulation—aimed at creating mathematical models help understand cerebrovascular disorders. The aim is produce computational model able assist in real-time interpretation clinical signals and guide decisions. reality are forced have artificial boundaries suggests these should be constructed ways allow easy communication/combination other At level testing, methodologies need developed for identifying parameters show considerable inter-individual variability or which very sensitive, thereby allowing them set using data. However, data cannot sufficient validate large physiological It important extract test submodels against appropriate, often vitro , A modular, computationally flexible, approach central building models; such an involves understanding manipulating logical structures underlie Issues inadequate information arbitrary circumvented, but they can planned by capable evolution.