A New 2D-Based Method for Carotid Intima-Media Thickness Quantification From Ultrasound Sequences

摘要: Background: Ultrasound measurement of carotid Intima-Media Thickness (IMT) is a suitable method to evaluate subclinical arteriosclerosis. Objectives: The current study aimed present new computerized algorithm detect instantaneous changes the IMT Common Carotid Artery (CCA) in sequential ultrasound images by applying maximum gradient and dynamic programming. Patients Methods: In cross-sectional design, an examination was performed on thirty healthy human subjects with mean age 44 ± 6 years from April 2013 June Beheshti Hospital, Kashan, Iran. all individuals, far wall CCA were extracted. Local measurements vessel intensity, intensity gradient, boundary continuity extracted for ultrasonic 2D-frames throughout three cardiac cycles. Pearson correlation coefficients Bland-Altman analysis assess relationship agreement between measured proposed conventional manual methods. Results: There no significant difference methods paired t-test (in systole: 0.57 0.10 vs. 0.56 mm; P = 0.188 diastole: 0.63 0.16 0.62 0.122 methods, respectively). r 0.94 0.93 s d , respectively (both < 0.001). Limit agreements narrow considerable found two Conclusions: demonstrated that analyzing can provide accurate 2D images.